LIF (Leukemia Inhibitory Factor) Polyclonal

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play essential roles in several different systems. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. LIF is commonly over-expressed in many solid cancers and recent studies have implicated LIF may be an useful new biomarker for early diagnosis of pancreatic cancer. Furthermore, LIF and its cognate receptor LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. LIF/LIFR axis is implicated as a promising clinical target for cancer therapy.