CCR6/CD196 [ZY912]

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Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Chromosome region maintenance 1 (CRM1), also known as Exportin-1, is a protein essential for nuclear export of hundreds of proteins, mRNAs, and rRNAs. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES). These hydrophobic sequences form an alpha-helix-loop that can bind to the exportin-1 hydrophobic groove. Studies have shown that these NESs can be modified either by protein modifications or by mutation to regulate exportin-1 binding. Targets of CRM1 include many tumor suppressors, such as Rb, p53, FoxO1, BAF47, as well as oncoproteins, such as p21 and p27.

Clone
ZY912

Isotype
IgG1

Host species
Mouse

Species Reactivity
Human

Cellular Localization
Membrane

Positive Control
Tonsil, Hodgkin’s lymphoma

Applications
IHC, FC

Intended Use
Research Use Only

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