CD248/TEM1/endosialin [MD206R]

CD248, also known as Tumor endothelial marker 1 (TEM1) or endosialin, consists of three EGF-like domains, a C-type lectin domain and a Sushi domain. It is a stromal cell marker highly expressed in expressed in lymphoid tissues during development, activated fibroblasts and in disease states where increased stromal cell proliferation and migration are evident, but not in most adult tissues. CD248 is highly upregulated in malignancies including breast cancer, brain tumors and sarcoma and is known to function in tumor growth and progression. CD248 gene is known to be upregulated in response to hypoxic conditions in the tumor environment through HIF2 activation. In liver fibrosis, CD248 marks the Hepatic Stellate Cells, the activated cells responsible for matrix production. In kidney fibrosis, CD248 marks the key effector cells within the fibrotic stroma including pericytes, myofibroblasts, and stromal fibroblasts, and in idiopathic pulmonary fibrosis, CD248 may be a marker for severity of disease and a major target in anti-angiogenic tumor therapy.