Cathepsin K protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
Clone
CTSK/2791
Isotype
IgG1k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
Cytoplasm
Positive Control
Osteosarcoma, ovary cancer
Applications
IHC
Intended Use
Research Use Only