Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Clone
Polyclonal
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
cytoplasm, membrane
Positive Control
breast or stomach ca
Applications
ELISA, IHC
Intended Use
Research Use Only