Ultra-Sensitive JAK2 mutation detection kit_V617

The Janus kinase 2 gene, also called JAK2, is a non-receptor tyrosine kinase which is involved in cytokine receptor signaling. Activated signaling of JAK2 causes phosphorylation of downstream signal transducers and activators of transcription (STAT) proteins ultimately leading to cell growth and differentiation. Somatic mutation V617F in JAK2 is found in patients with blood related disease, such as polycythemia vera, Thrombocythemia, chronic myelomonocytic leukemia, which may lead to the uncontrolled or abnormal proliferation of blood cells.