UHMK1/KIST Polyclonal

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. UHMK1 (U2AF homology motif kinase 1), also known as KIS (kinase interacting with stathmin) or KIST, is a 419 amino acid nuclear protein that contains one protein kinase domain and one RRM domain and belongs to the Ser/Thr protein kinase family. Expressed in a variety of tissues with highest levels present in placenta, kidney and skeletal muscle, UHMK1 functions to catalyze the ATP-dependent phosphorylation of target proteins, such as p27, and is thought to be involved in cell cycle regulation, as well as in the trafficking and processing of RNA. Multiple isoforms of UHMK1 exist due to alternative splicing events.