Ubiquitin-conjugating Enzyme E2C/UBE2C/UBCH10 [MD387]

The ubiquitin pathway involves three sequential enzymatic steps that facilitate the conjugation of ubiquitin and ubiquitin-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the ubiquitin C-terminus and the assembly of multi-ubiquitin chains by the ubiquitin-activating enzyme known as the E1 component. The ubiquitin chain is then conjugated to the ubiquitin-conjugating enzyme (E2) to generate an intermediate ubiquitin-E2 complex. The ubiquitin-ligase (E3) then catalyzes the transfer of ubiquitin from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an ubiquitin-conjugating enzyme E2 for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.