TROP2/TACD1 [TACSTD2/2153]

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TROP2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factorlike repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment.

Catalog No. MC0386, MC0386RTU7

Clone
TACSTD2/2153

Isotype
IgG1k

Host species
Mouse

Species Reactivity
Human

Cellular Localization
membrane, some cytoplasm

Positive Control
skin, breast or cervical cancer, MCF7 and HCT 116 cells

Applications
ELISA, IHC

Intended Use
Research Use Only

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