TPO/Thyroid Peroxidase [MD118R]

Thyroid Peroxidase (TPO) is a membrane-bound protein, catalyzing iodide oxidation, iodination of tyrosine residues and generation of triiodothyronine and thyroxine. It is first synthesized within the endoplasmic reticulum (ER), where it can be readily detected. After folding to the native state within the ER, intracellular transport of TPO to the cell surface occurs via the Golgi complex, a compartment typically associated with N-glycan processing of many cell surface glycoproteins. TPO labels normal thyroid epithelial cells and thyroid tumor cells. The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors.