Topoisomerase (DNA) I Mitochondrial (TOP1MT) [TOP1MT/488]

$520.00

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DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

Catalog No. MC0094

Clone
TOP1MT/488

Isotype
IgG2b/k

Host species
Mouse

Species Reactivity
Human

Cellular Localization
membrane

Positive Control
urinary bladder, urothelial carcinoma

Applications
ELISA, IHC

Intended Use
Research Use Only

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