DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Catalog No. MC0094
Clone
TOP1MT/488
Isotype
IgG2b/k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
membrane
Positive Control
urinary bladder, urothelial carcinoma
Applications
ELISA, IHC
Intended Use
Research Use Only