TOM34 Polyclonal

TOM34 (translocase of outer mitochondrial membrane 34), also known as TOMM34, URCC3 or HTOM34P, is a ubiquitously expressed 309 amino acid protein that contains six TPR repeats. Localized to the cytoplasmic side of the mitochondrion, TOM34 is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. Expression of TOM34 is upregulated in colon cancer cells and is thought to be involved in tumor progression. TOM34 may, therefore, be a novel target for therapeutic anti-cancer drugs.