TMTC4 Polyclonal

A family of four homologous genes that encode transmembrane and tetratricopeptide repeat (TPR) containing protein has been identified as TMTC1-4. The fate and function of many cellular processes in normal and abnormal cells depend on the number of tetratricopeptide repeats clusters and their ability to bind to specific types of ligand proteins. At least three consecutive TPR domains are required to form a functional unit of the protein. Although the exact functions and molecular pathways related to these molecules are still to be uncovered, few studies suggested that they have roles in the endoplasmic reticulum (ER) function, unfolded protein response (UPR), and pathways related to cadherins (CDHs) and protocadherins (PCDHs). Recently, the role of these pathways in carcinogenesis is being explored and targeted. Therefore, the identification of new regulatory molecules may have possible diagnostic and therapeutic implications. Studies show that high TMTC4 expression in PCa cells helps differentiate between PCa and BPH with high sensitivity and specificity.