TFF1/pS2 [MD119R]

Trefoil factor 1 (TFF1), a member of the trefoil factor family, also known as protein pS2 or breast cancer estrogen-inducible protein, is a stabilizer of the mucus gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract. The TFF1 antibody labels gastric mucosal cells, goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, epithelial cells lining the exocrine pancreatic ducts and breast epithelial cells.