STAB1/Stabilin1 Polyclonal

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STAB1 or Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.

Catalog No. RC0138, RC0138RTU7

Clone
Polyclonal

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human, mouse, rat

Cellular Localization
membrane

Positive Control
spleen

Applications
IF, IHC

Intended Use
Research Use Only

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