SSX gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur low frequency.
Clone
Polyclonal
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
Nucleus
Positive Control
Breast cancer, colon and colon cancer, ovary and ovary cancer, bladder cancer
Applications
IHC
Intended Use
Research Use Only