SSR5 Polyclonal

Somatostatin receptor type 5 or SSR5 is encoded by the SSTR5 gene in human. Somatostatin receptor type 5 is an inhibitory G-protein coupled receptor (GPCR) which regulates hormone secretion in the pituitary and in pancreatic islets. SSTR5 uses its PDZ ligand motif to interact with PSD-95/discs large/ZO-1 (PDZ) domain proteins, such as the Golgi-associated protein PIST (also termed GOPC, CAL or FIG), endosomal sorting nexin 27 (SNX27), and the scaffold proteins NHERF-1 & NHERF-3 (PDZ-K1). SNX27 is reported to stabilize SSTR5 by preventing its lysosomal degradation, while NHERF-1 & NHERF-3 mediate SSTR5 plasma membrane localizatin and enable its coupling to signaling partners, such as phospholipase C-β3. PIST stabilizes SSTR5 association with the trans-Golgi network (TGN) before it is recruited to the plasma membrane by NHERF proteins.