SIRT6 Polyclonal

The Silent Information Regulator (Sir2) genes encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a chromatin-associated nuclear ADP-ribosyltransferase protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SIRT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway. It appears to be involved in DNA repair and may also play a role in human aging.