SF1/Steroidogenic Factor 1 [MD95]

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Steroidogenic factor-1 (SF-1), also known as NR5A1, regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells. Overexpression or overactivity of SF-1 is also reported in some adrenal tumors or endometriosis. Therefore, the spectrum of phenotypes associated with variations in SF-1 is expanding and the importance of this nuclear receptor in human endocrine disease is now firmly established.

Catalog No. MC0210, MC0210RTU7

Clone
MD95

Isotype
IgG2b/k

Host species
Mouse

Species Reactivity
Human

Cellular Localization
nucleus

Positive Control
Testis, ovary, thymus

Applications
IHC

Intended Use
Research Use Only

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