The Sal-like protein 4, SALL4 is a zinc finger transcription factor located on chromosome 20q13.13-13.2. It is essential during development by maintaining embryonic stem cell pluripotency and self-renewal. Mutations in SALL4 lead to acro-renal-ocular and Okihiro syndromes, a disorder of the eyes and abnormalities of bones in the arms and hands. Recently, SALL4 has been identified as a novel sensitive diagnostic marker for germ cell tumors. Strong SALL4 staining was observed in all seminoma/dysgerminoma/germinomas, embryonal carcinomas, and yolk sac tumors, yielding 100% sensitivity for these malignancies. Compared with _-fetoprotein and glypican-3, SALL4 demonstrated superior sensitivity in detecting yolk sac tumors. Focal SALL4 staining was also observed in choriocarcinomas (66-71%) and teratomas (50-64%). In non-germ cell tumors, SALL4 is expressed in all cases of acute myeloid leukemia, and majority of precursor B-cell acute lymphoblastic lymphomas (79%). In a large immunohistochemical study of >3200 cases, SALL4 was also detected in ~20% of cases of ovarian, urothelial and gastric adenocarcinomas, and <5% in mammary, colorectal, prostatic and squamous cell carcinomas.
Clone
6E3
Isotype
IgG1
Host species
Mouse
Species Reactivity
Human, mouse
Cellular Localization
Nucleus
Positive Control
Yolk sac tumor, testis
Applications
ELISA, IHC, WB
Intended Use
Research Use Only