RAGE [MD367]

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor on the surface of endothelial cells, mononuclear phagocytes, and vascular smooth muscle cells, where RAGE functions as a key receptor for advanced glycation end products (AGEs), S100 proteins, and high-mobility group box 1 (HMGB1). RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-β peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. RAGE ia implicated in the pathogenesis of numerous chronic diseases such as diabetes, atherosclerosis, Alzheimer′s disease, and other inflammatory and vascular disorders. This antibody serves as an indispensable tool for researchers seeking to elucidate the intricate roles of RAGE in various disease states and to explore potential strategies for therapeutic intervention.