Podoplanin [D2-40]

D2-40, also known as Podoplanin and Lymphatic Endothelial Cell Marker. It is expressed in lymphatic endothelium, and was found in lymphangiomas, Kaposi sarcomas, a subset of angiosarcomas with lymphatic differentiation, epithelioid mesotheliomas, hemangioblastomas, seminomas. D2-40 is a useful marker in identification of lymphatic invasion of primary tumors. D2-40 has also known to be a specific marker for cells of mesothelial origin, e.g. mesothelioma.