Plasma Cells [LIV3G11 (7B18)]

Plasma cells, which are large lymphocytes derived from an antigen-specific B-cell, secrete
antibodies and are responsible for humoral immunity. Plasma cells differentiate from B-cells
upon stimulation by CD4+ lymphocytes. Plasma cells contain basophilic cytoplasm; their
nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This
antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed,
paraffin-embedded tissue sections. It is of potential value in identifying myeloma or
plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid
lymphoma from lymphocytic and follicular lymphoma. Note that this antibody is not suitable for
staining frozen tissues.