PHLDA1 (TDAG51) [RN-6E2]

PHLDA1 (pleckstrin homology-like domain family A member 1), also known as TDAG51, encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. In activated T lymphocytes, PHLDA1 works with T-cell receptor to inhibit protein biosynthesis. It is also responsible for differentiation of trichoepithelioma from basal cell carcinomas (BCCs). PHLDA1 is down-regulated in primary, and metastatic melanomas and breast cancer. On the other hand, it is involved with migration and proliferation in colon cancer cells. PHLDA1 is also involved in development of atherosclerosis in presence of hyperhomocysteinemia.