PAX3 [C2]

$454.00

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PAX3 (Paired Box 3) is a member of the paired box (PAX) family of transcription factors involved in development of the peripheral nervous system, melanocytes, some vascular smooth muscle, and a number of other derivatives. It regulates neurogenesis in pre-migratory neural crest cells from the dorsal neural tube, and in myogenic progenitors in the presomitic mesoderm and the hypaxial somites. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Clone
C2

Isotype
IgG2a

Host species
Mouse

Species Reactivity
Human, amphibian, chicken, fish, mouse, quail, rat, zebrafish

Cellular Localization
nucleusR1409

Positive Control
colon carcinoma lysates, esophageal carcinoma, brain tissues

Applications
Flow Cyt., IF, IHC, IP, WB

Intended Use
Research Use Only

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