Parathyroid Hormone (N-Terminal) (PTH) [3H9]

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PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Catalog No. MC0907, MC0907RTU7

Clone
3H9

Isotype
IgG2b/k

Host species
Mouse

Species Reactivity
Human, predicted to react with mouse, rat, rabbit, cow, dog, pig, deer and orangutan

Cellular Localization
cytoplasm, secreted

Positive Control
parathyroid gland

Applications
Flow Cyt., IF, IHC

Intended Use
Research Use Only

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