p63 [4A4]

The p63 protein is a member of the p53 family, which also includes p73. At least 6 different transcripts of p63 derives from alternative splicing events and encodes proteins with two different N termini (TA and DN) and three different C termini (a, b and g). p63 protein is detected in proliferating cells of epithelium, cervix, urothelium and prostate. It is also expressed in most poorly differentiated squamous cell carcinomas. The delta Np63 isoform is also abundantly expressed in nasopharyngeal carcinomas. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. These basal cells act as the progenitors of the suprabasal cells, which undergo differentiation and cell death in regenerative epithelia. p63 is also an essential gene that is critical for regenerative proliferation of cells involved in limb, craniofacial and epidermal morphogenesis.