Adapter protein Sequestosome 1 (SQSTM1, p62) is an ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Defects in SQSTM1 are a cause of Paget disease of bone (PDB). PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma.
Clone
MD61
Isotype
IgG1
Host species
Mouse
Species Reactivity
Human
Cellular Localization
Cytoplasm
Positive Control
Lymph node, colon cancer, lung cancer
Applications
ICC/IF, IHC, WB
Intended Use
Research Use Only