p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is overexpressed in over 50% of human cancers. Positive staining of p53 detected by immunohistochemistry has been observed in colon cancer, breast cancer, lung cancer, prostate cancer and ovary cancer.
Catalog No. MC0219, MC0219RTU7
Clone
DO-7
Isotype
IgG2b/κ
Host species
Mouse
Species Reactivity
Human, mouse, rat, cow, monkey
Cellular Localization
nucleus
Positive Control
breast ca, colon ca
Applications
Flow +Q1378+T1386
Intended Use
Research Use Only