p504S (AMACR) [13H4]

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AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma, but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker. High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma, but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34βE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.

Catalog No. RM0215, RM0215RTU7

Clone
13H4

Isotype
IgG

Host species
Rabbit

Species Reactivity
Human

Cellular Localization
cytoplasm

Positive Control
prostate adenoca

Applications
IHC

Intended Use
Research Use Only

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