p34/CDC2/CDK1 [POH-1]

p34cdc2 is a phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the cell cycle. It is the catalytic subunit of the maturation-promoting factor (MPF) and complexes with both cyclin A and B in mammalian cells. Activated p34cdc2 kinase phosphorylates a variety of substrates, leading to some specific events of mitosis, including nuclear envelope break-down and chromosome condensation. p34cdc2 has also been implicated in lymphoid proliferation.