MAGEC2/CT10 [LX-CT10.5]

Melanoma-associated antigen C2 (MAGEC2) is one of cancer-testis (CT) antigens which expresses in normal testis and placental tissue. Normally, MAGEC2 or CT10 expression is restricted to male germ cells in the testis however, MAGEC2 is abnormally expressed in a wide variety of malignancies, including hepatocellular carcinoma, melanoma, bladder cancer, breast cancer, sarcoma, and lung cancer. MAGEC2 positive tumors are associated with reduced overall survival rates in prostate, hepatocellular, breast, and non-small cell lung carcinomas. In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma. MAGEC2 plays a critical role in promoting breast cancer progression via the induction of EMT, which escalates the motility and invasiveness of tumor cells. Since MAGEC2 is highly expressed in cancer cells but absent from normal adult tissues it is considered an ideal target for cancer immunotherapy. This antibody is useful for identifying MAGEC2 expressing cells in immunohistochemical studies.