LHRH Receptor/GnRHR [F1G4]

Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The GnRH receptor (GnRHR), like most G protein-coupled receptors, contains a seven transmembrane domain. However, unlike most G protein-coupled receptors, the GnRHR lacks an intracellular C-terminal domain. The GnRHR gene is thought to be regulated by GnRH and activin A, and has been shown to undergo alternative splicing.