LECT2 (Leukocyte cell-derived Chemotaxin 2) [MD391]

LECT2 (Leukocyte cell-derived Chemotaxin 2) is made in liver and released to circulation with multiple biologic functions, including in liver regeneration and fibrogenesis. LECT2 amyloidosis is a rare form of systemic amyloidosis with frequent liver involvement. Structurally, LECT2 consists of 133 amino acids and features three intramolecular disulfide bonds that contribute to LECT2′s stability and functional versatility. Notably, homologues of LECT2 have been identified across various vertebrate species, indicating LECT2′s evolutionary significance. The multifunctional role of LECT2 encompasses processes such as cell growth, differentiation, tissue damage repair, carcinogenesis, and the modulation of autoimmune diseases. Furthermore, LECT2 expression is specifically induced in the liver through β-catenin signaling pathways, and elevated serum levels of LECT2 have been associated with liver recovery, suggesting LECT2′s potential utility as a prognostic biomarker in liver-related conditions.