IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. It plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. It is involved in host defense, acute phase reactions, immune responses, and hematopoiesis.
Clone
MD236
Isotype
IgG1k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
cytoplasmic , extracellular (secreted)
Positive Control
heart
Applications
IHC
Intended Use
Research Use Only