IDH2 (Isocitrate Dehydrogenase 2) [MD68R]

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses that utilize either NAD or NADP+ as an electron acceptor. Five isocitrate dehydrogenases have been reported: three NAD dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP+ dependent isocitrate dehydrogenases, one of which is mitochondrial (IDH2) and the other predominantly cytosolic (IDH1). Each NADP+ dependent isozyme is a homodimer. IDH2, a 452 amino acid enzyme, is involved in the reduction of NADP+ to NADPH and maintains mitochondrial glutathione levels. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.