Human Epididymis Protein 4/HE4/WFDC2 [5B2D9]

The Human Epididymis Protein 4 (HE4), also named WAP four-disulfide core domain protein 2 (WFDC2), is a 25 kDa secreted glycoprotein and is expressed in the epididymis, uterus, and tracheal tissues. HE4 is expressed in a number of normal tissues, and it is also highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. The value of serum HE4 as a biomarker for ovarian and endometrial cancers has been well recognized. Overexpression of HE4 enhanced the malignant behavior of cancer cells including proliferation, invasion, and colony formation. Studies have shown HE4 expression in other malignant tumors including lung adenocarcinoma, stomach cancer and pancreatic cancer.