HLA-E (MHC I) [MD364]

Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-E). MHC class I molecules consist of two polypeptide chains, an a or heavy chain and a non-covalently associated protein, β-2-Microglobulin. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encoded by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralogs. HLA-E is a heterodimer consisting of a heavy chain and a light chain. The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.