H3K27M [RM192] for Neuropathology

$516.00

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Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ‘beads on a string’ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Histone variant H3.3 is typically enriched in active chromatin.

Clone
RM192

Isotype
IgG

Host species
Rabbit

Species Reactivity
All

Cellular Localization
nucleus, chromosome

Positive Control
“brain with mutaH3.3 mutated K27M, 293T cells transfected with a DNA construct encoding Histone H3 K27M mutant”

Applications
ELISA, ICC/IF, IHC, WB

Intended Use
Research Use Only

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