GLEPP1 (Glomerular Epithelial Protein 1) [MD377R]

Glomerular Epithelial Protein 1 (GLEPP1) is a transmembrane protein tyrosine phosphatase found only in the epithelial cells of the renal glomerulus. It is localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. It may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. GLEPP-1 is present only in visceral glomerular cells (Podocytes). The presence of GLEPP1 may be used as a marker of podocyte integrity in various forms of glomerular injury.