GADD34 [A4D7]

Growth arrest and DNA damage-inducible protein GADD34 also known as protein phosphatase 1 regulatory subunit 15A PPP1R15A is a protein encoded by the PPP1R15A gene in humans. The Gadd34 (also designated MyD116) gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. PEG-3 (progression elevated gene-3) shares significant homology with GADD 34 and is inducible by DNA damage. PEG-3 expression has been shown to be elevated in cells displaying a progressed-transformed phenotype. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.