FOLR1/FRα/FBP [MD255R]

FOLR1 (folate receptor 1 or folate receptor alpha) is a 38-40 kDa glycosylphosphatidylinositol (GPI)-anchored cell surface protein encoded by the FOLR1 gene. Folate receptor alpha is primarily expressed in the apical surface of some polarized epithelial cells of normal tissues (such as kidney, lung, breast, and salivary glands) and on malignant tumors such as epithelial ovarian cancer (EOC), thyroid cancer, non-small cell lung adenocarcinoma (NSCLC) and endometrial cancer. Studies show that the expression of FOLR1 in EOC increases with tumor stage, and is associated with decreased survival. In NSCLC, FOLR1 has been shown to be specific for adenocarcinomas relative to squamous cell carcinoma and other histologic subtypes, and increased expression has been correlated to increased survival. FOLR1 has been exploited as a target for specific delivery of chemotherapy and immunotherapy agents. This antibody specifically recognizes human FOLR1.