vWF, as known as Factor VIII related antigen (Factor VIII RA), is a sensitive marker of benign blood vessels and has been used for the study of angiogenesis in neoplasm such as breast cancer. vWF is seldom expressed in poorly differentiated vascular tumors. Therefore, anti-vWF antibody must be used in conjunction with other more sensitive markers of endothelial cells (e.g. CD34 and CD31) when identifying angiosarcomas. There is overlap between the expression of von Willebrand factor in vascular and lymphatic endothelium.
“vWF, as known as Factor VIII related antigen (Factor VIII RA)
, is a sensitive marker of benign blood vessels and has been used for the study of angiogenesis in neoplasm such as breast cancer. vWF is seldom expressed in poorly differentiated vascular tumors. Therefore, anti-vWF antibody must be used in conjunction with other more sensitive markers of endothelial cells (e.g. CD34 and CD31) when identifying angiosarcomas. There is overlap between the expression of von Willebrand factor in vascular and lymphatic endothelium. “
Clone
VWF/1859R
Isotype
IgG
Host species
Rabbit
Species Reactivity
Human
Cellular Localization
cytoplasm
Positive Control
placenta
Applications
IHC, WB
Intended Use
Research Use Only