DHH [MD389]

DHH gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that functions in the regulation of cell growth and differentiation, making Dhh essential for proper organogenesis and maintenance of stem cell populations. The C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. Understanding Dhh function and modifications is important for elucidating developmental biology roles and potential implications in diseases such as cancer, where hedgehog signaling can be aberrantly activated.