Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Clone
7H8.2C12
Isotype
IgG2b/k
Host species
Mouse
Species Reactivity
Human, mouse, rat, horse, dog, pigeon, frog, drosophila
Cellular Localization
cytoplasm
Positive Control
heart
Applications
Flow Cyt, ICC/IF IHC, WB
Intended Use
Research Use Only