CRP/C Reactive Protein Polyclonal

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a plasma protein involved in host defense by promoting agglutination, bacterial capsular swellling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It also scavenges nuclear material released from damaged circulating cells. The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. CRP has two isoforms produced by alternative splicing. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Measurements of CRP in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.