CD71, the transferrin receptor, is a type II trans-membrane homodimer glycoprotein (180 kDa) involved in the cellular uptake of iron via internalization of iron-loaded transferring. CD71 is highly expressed in immature erythroid cells, placental tissue and rapidly dividing cells. Loss of CD71 is observed in mature erythrocytes. Over expression of CD71 has also been described for various types of cancers including lung, colon, breast and pancreas. CD71 antibody is useful in identifying erythroid precursors.
Clone
TFRC/1817
Isotype
IgG2b/k
Host species
Mouse
Species Reactivity
Human
Cellular Localization
membrane
Positive Control
breast ca, placenta
Applications
IHC, ELISA
Intended Use
Research Use Only