CD32 [B4]

CD32, also known as Fc gamma RII, is a low affinity receptor for the Fc fragment of aggregated IgG. This polymorphic transmembrane glycoprotein is expressed on B cells, granulocytes, monocytes, macrophages, and platelets. It is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells. CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C. These isoforms are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC. CD32 enables interaction between Fc gammaRII-expressing cells and opsonized antigen or IgG-containing immune complexes. Both receptors exhibit low affinity towards IgG and play a role in inflammation and autoimmune disease. This clone detects the CD32-A/B/C protein of mouse, rat and human origin.