CD204/MSR1/SR-A [MD405]

The scavenger receptor class A (SR-A), also known as Macrophage Scavenger receptor types I and II (MSR1) or CD204, are members of the class A macrophage scavenger receptor family. These proteins bind large quantities of modified lipoproteins and promote endocytosis. SR-A plays a crucial role in lipid metabolism by mediating the uptake of modified LDL, which is significant for understanding atherosclerosis and other lipid-related diseases. SR-A expression occurs predominantly in the liver, placenta, and brain. Upregulation of SR-A in infiltrating myeloid cells may mediate clearance of specific damage signals in response to tissue injury, including ischemic stroke. SR-A germline mutations are also associated with increased prostate cancer susceptibility in some patient cohorts. SR-A contributes to various macrophage-associated pathological processes, including atherosclerosis and Alzheimer′s disease, as well as host defense and cellular adhesion.