CD155/PVR [MD212R]

CD155 aka the poliovirus receptor (PVR) or nectinlike molecule 5 (Necl-5), a member of the nectin family of cell adhesion molecules and tumor antigen, is ectopically expressed in certain cancers, such as glioblastoma multiforme (GMB) and lung adenocarcinoma, and plays an important role in tumor cell migration, invasion, and metastasis. Studies show that CD155-positivity was associated with aggressive tumor behavior, and was a factor to predict a poor prognosis. Its prognostic impact was enhanced when combined with PD-L1 expression status. CD155 expression in glioblastoma cells renders them susceptible to PV infection and killing, an indispensable aspect of PVSRIPO immunotherapy (oncolytic polio-rhinovirus recombinant vaccine). Availability of a robust IHC assay for detecting CD155 will enable preclinical assessments of the suitability of PVSRIPO immunotherapy in cancers.